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IGFBP-1

Insulin-like growth factor-binding protein-1(IGFBP-1) is synthesized and secreted by fetal or adult liver cells and decidualized endometrial cells during pregnancy. In maternal circulation, the concentration of IGFBP-1 increases after pregnancy, and IGFBP-1 is a major protein from the beginning of the second trimester to childbirth in amniotic fluid. 

Premature rupture of fetal membranes (PROM) refers to rupture of fetal membranes before onset of labor. In perinatal period,PROM is relatively common complication as its occurrence rate is about 10%. PROM may cause serious consequences such as increased risk of preterm delivery rates, perinatal mortality and intra-amniotic infection.

IGFBP-1 is a highly sensitive biomarker for early diagnosis of PROM. IGFBP-1 could be sensitively detected in vaginal fluid after the leakage of tiny amounts of amniotic fluid as the concentration of IGFBP-1 in amniotic fluid is 100 to 1000 fold higher compared to that in human blood.

Catalog Product Name Type Function Application
CSB-DP286I Human Insulin-like growth factor-binding protein 1(IGFBP-1) Antigens
Fertility & Hormones
Calibrator or standard in ELISA, WB, GICA and other possible application
CSB-DA286GmN② Mouse anti-human Insulin-like growth factor-binding protein 1(IGFBP-1) monoclonal antibody Monoclonal Antibodies
Fertility & Hormones
LFIA
CSB-DA286GmN① Mouse anti-human Insulin-like growth factor-binding protein 1(IGFBP-1) monoclonal antibody Monoclonal Antibodies
Fertility & Hormones
LFIA
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