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MPO

Myeloperoxidase (MPO) is a hemoprotein that is abundantly expressed in neutrophils and secreted during their activation. The 150-kDa MPO protein  is a cationic homodimer consisting of two covalently bound subunits,each consists of a heavy chain (MW 60kDa) and a light chain (MW 15kDa).

MPO plays an important role in inflammatory response by zapping microorganisms and destroying a variety of target materials through catalyzing chloride ion oxidation to hypochlorous acid in the phagocytic cells. On the other hand, MPO causes oxidative modification of low density lipoprotein (LDL) to a high uptake form that is considered to be a key event in the promotion of atherogenesis. For this reason, MPO is believed to participate in the initiation and progression of cardiovascular diseases. 
At present, MPO is considered to be one of the most promising cardiovascularmarkers and the rise of MPO levels indicates the increased risk of atherosclerosis and coronary heart disease (CHD).

MPO level can be increased significantly within two hours for chest pain. Hence, MPO is an early warning marker of myocardial infarction and can be earlier to predict the risk of disease than troponin T, CK-MB and CRP. For patients with chest pain,MPO is then important and clinically significant in the diagnosis of Acute Coronary Syndrome (ACS).

Catalog Product Name Type Function Application
CSB-DA406HmN② Mouse anti-human Myeloperoxidase(MPO) monoclonal antibody Monoclonal Antibodies
Cardiovascular Disease
LETIA,ELISA, CLIA, LFIA
CSB-DA406HmN① Mouse anti-human Myeloperoxidase(MPO) monoclonal antibody Monoclonal Antibodies
Cardiovascular Disease
LETIA,ELISA, CLIA, LFIA
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