Alzheimer
Alzheimer's disease (AD) is a progressive neurodegenerative disease with insidious onset. Clinically, it is characterized by comprehensive dementia symptoms such as memory impairment, aphasia, apraxia, agnosia, visuospatial skill impairment, executive dysfunction and personality and behavioral changes. The cause is still unknown. Diagnosis is generally made through clinical manifestations, neurological scales, imaging examinations, biomarker examinations and pathological diagnosis. Among them, corresponding serum and cerebrospinal fluid biomarker examinations are important diagnostic basis.
COSAGEX can provide diagnostic reagent raw materials for Alzheimer's disease, mainly involving Aβ42 and P-Tau, for customer reagent development.
Aβ40
Aβ is a fragment of 39-43 amino acids in length that is cleaved from β-amyloid precursor protein (APP) by proteolytic pathways. They are all produced by the continuous cleavage of APP by β-secretase and γ-secretase. Proliferation and mutation of the APP gene and mutations in the presenilin genes (PSEN1 and PSEN2) can lead to familial Alzheimer’s disease. Although the variability of γ-secretase cleavage leads to different sizes of Aβ peptides, Aβ40 and Aβ42 are the most abundant, and Aβ42 has greater neuronal toxicity. Studies have shown that the assembly of Aβ42 filaments is a core event in Alzheimer’s disease.
● Monoclonal Antibody
| Product Name | Catalogue # | Specification |
|---|---|---|
| Amyloid β-protein 40 (Aβ40) | CSB-DA627AmN① | Specification |
| Amyloid β-protein 40 (Aβ40) | CSB-DA627AmN② | Specification |
● Recombinant Protein
| Product Name | Catalogue # | Specification |
|---|---|---|
| Amyloid β-protein 40 (Aβ40) | CSB-DP627B | Specification |
Aβ42
Aβ is a fragment of 39-43 amino acids in length that is cleaved from β-amyloid precursor protein (APP) by proteolytic pathways. They are all produced by the continuous cleavage of APP by β-secretase and γ-secretase. Proliferation and mutation of the APP gene and mutations in the presenilin genes (PSEN1 and PSEN2) can lead to familial Alzheimer’s disease. Although the variability of γ-secretase cleavage leads to different sizes of Aβ peptides, Aβ40 and Aβ42 are the most abundant, and Aβ42 has greater neuronal toxicity. Studies have shown that the assembly of Aβ42 filaments is a core event in Alzheimer’s disease.
● Monoclonal Antibody
| Product Name | Catalogue # | Specification |
|---|---|---|
| Amyloid β-protein 42 (Aβ42) | CSB-DA900AmN① | Specification |
● Recombinant Protein
| Product Name | Catalogue # | Specification |
|---|---|---|
| Amyloid β-protein 42 (Aβ42) | CSB-DP900B | Specification |