Methylation & Demethylation Enzymes
DNA methylase is a modification enzyme that often occurs with restriction enzymes. In eukaryotic and prokaryotic genomes, it is common to maintain and catalyze DNA methylation by DNA methylase. DNA methylase is widely regarded as a therapeutic target and a marker for predicting biological methylation process. Accurate and sensitive detection of DNA methylase at the single-cell level plays a crucial role in clinical diagnosis, clinical treatment and even biological research of tumor medicine. DNA demethylation refers to the demethylation of DNA in mammalian cells due to the lack and reduction of intracellular DNA methyltransferase content, which plays an important role in the initiation of specific gene expression and reprogramming. The mechanism of active DNA demethylation has long been one of the most fundamental questions in the field of epigenetics.